Familial clustering of severe atypical variants of erythema nodosum leprosum in immunocompetent siblings

Familial clustering of severe atypical variants of erythema nodosum leprosum in immunocompetent siblings

Erythema nodosum leprosum is characterised by brightly erythematous tender nodules or plaques usually in bilateral symmetrical distribution. ENL can also present in several atypical presentations like pustular, erythema multiform like, ulcerative, necrotic, panniculitic and bullous forms. Various precipitating factors for ENL include stress, pregnancy, surgery, lactation, menstruation, infectio...

Erythema nodosum leprosum.

Etanercept in erythema nodosum leprosum*

One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of sid...

T-cell regulation in Erythema Nodosum Leprosum

Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. However, immune-complexes and cell-mediated immunity have been suggeste...

Complement C1q expression in Erythema nodosum leprosum

Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction. In the present study we described the protein level of C1q production and its gene expressi...